26S Proteasome Regulatory Subunit 8 (PSMC5) Antibody (FITC)

26S Proteasome Regulatory Subunit 8 (PSMC5) Antibody (FITC) is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 8 (PSMC5) conjugated to FITC. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.

Target	26S Proteasome Regulatory Subunit 8 (PSMC5)
Clonality	Polyclonal
Reactivity	Human
Host	Rabbit
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	FITC
Excitation/Emission	499/515
Laser Line	488
Immunogen	Recombinant Human 26S protease regulatory subunit 8 protein (253-324AA).
Isotype	IgG
Form	Liquid
Purity	> 95%
Purification	Purified by Protein G.
Storage	Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P62195 (UniProt, ExPASy)
UniProt Secondary AC	A8K3Z3, A8K763, O35051, O43208, P47210, P52915, P52916
UniProt Entry Name	PRS8_HUMAN
Gene Symbol	PSMC5
GeneID	5705
OMIM	601681
NCBI Accession	NP_001186092.1 NM_001199163.1 NP_002796.4 NM_002805.5
KEGG	hsa:5705
String	9606.ENSP00000310572
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 8 (PSMC5)

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