26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11) Antibody

26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11) Antibody is a Rabbit Polyclonal against 26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene.

Target	26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/200, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	proteasome(prosome, macropain) 26S subunit, non-ATPase, 11
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	O00231 (UniProt, ExPASy)
UniProt Secondary AC	A8K3I7, E1P663, O00495, Q53FT5
UniProt Entry Name	PSD11_HUMAN
Gene Symbol	PSMD11
GeneID	5717
OMIM	604449
NCBI Accession	NP_001257411.1 NM_001270482.1
HGNC	9556
KEGG	hsa:5717
Ensembl	ENSG00000108671
String	9606.ENSP00000261712
Molecular Weight	Observed MW: 47 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 11 (PSMD11)

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