26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12) Antibody

26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12) Antibody is a Rabbit Polyclonal against 26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	ELISA: 1/40000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Synthesized peptide derived from the Internal region of human PSMD12.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O00232 (UniProt, ExPASy)
UniProt Secondary AC	A6NP15, Q53HA2, Q6P053
UniProt Entry Name	PSD12_HUMAN
Gene Symbol	PSMD12
GeneID	5718
OMIM	604450
NCBI Accession	NP_001303270.1 NM_001316341.1 NP_002807.1 NM_002816.4
HGNC	9557
KEGG	hsa:5718
Ensembl	ENSG00000197170
String	9606.ENSP00000348442
Buffer	PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12)

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