26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12) Antibody
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Catalogue No: abx031378
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(Size: 80 µl)
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Datasheet SDS
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.
Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12)
| Target | 26S Proteasome Non-ATPase Regulatory Subunit 12 (PSMD12) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 276-304 amino acids from the Central region of human PSMD12. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O00232 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NP15, Q53HA2, Q6P053 |
| UniProt Entry Name | PSD12_HUMAN |
| Gene Symbol | PSMD12 |
| GeneID | 5718 |
| OMIM | 604450 |
| NCBI Accession | NP_001303270.1 NM_001316341.1 NP_002807.1 NM_002816.4 |
| HGNC | 9557 |
| KEGG | hsa:5718 |
| Ensembl | ENSG00000197170 |
| String | 9606.ENSP00000348442 |
| Molecular Weight | Calculated MW: 52.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow PSMD12. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |