26S Proteasome Non-ATPase Regulatory Subunit 13 (PSMD13) Antibody

26S Proteasome Non-ATPase Regulatory Subunit 13 (PSMD13) acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described.

Target	26S Proteasome Non-ATPase Regulatory Subunit 13 (PSMD13)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 269-298 amino acids from the C-terminal region of human PSMD13.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UNM6 (UniProt, ExPASy)
UniProt Secondary AC	B3KT15, O75831, Q53XU2, Q9UNV3
UniProt Entry Name	PSD13_HUMAN
Gene Symbol	PSMD13
GeneID	5719
OMIM	603481
NCBI Accession	NP_002808.3 NM_002817.3 NP_787128.2 NM_175932.2
HGNC	9558
Ensembl	ENSG00000185627
Molecular Weight	Calculated MW: 42.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Chicken PSMD13.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 13 (PSMD13)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue