26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) Antibody
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Catalogue No: abx031274
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US$326.25
(Size: 80 µl)
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Datasheet SDS
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4)
| Target | 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 300-328 amino acids from the C-terminal region of human PSMD4. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P55036 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DV16, Q5VWC5, Q9NS92 |
| UniProt Entry Name | PSMD4_HUMAN |
| Gene Symbol | PSMD4 |
| GeneID | 5710 |
| OMIM | 601648 |
| NCBI Accession | NP_002801.1 NM_002810.2 |
| HGNC | 9561 |
| KEGG | hsa:5710 |
| Ensembl | ENSG00000159352 |
| String | 9606.ENSP00000357879 |
| Molecular Weight | Calculated MW: 40.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |