26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) Antibody

PSMD4 Antibody is a Rabbit Polyclonal antibody against PSMD4. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

Target	26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human PSMD4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P55036 (UniProt, ExPASy)
UniProt Secondary AC	D3DV16, Q5VWC5, Q9NS92
UniProt Entry Name	PSMD4_HUMAN
Gene Symbol	PSMD4
GeneID	5710
OMIM	601648
NCBI Accession	NP_002801.1 NM_002810.2
HGNC	9561
KEGG	hsa:5710
Ensembl	ENSG00000159352
String	9606.ENSP00000357879
Molecular Weight	Calculated MW: 41 kDa Observed MW: 50 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	3.25 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4)

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