Proteasome Activator Subunit 3 (PSME3) Antibody

PSME3 Antibody is a Rabbit Polyclonal antibody against PSME3. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants.

Target	Proteasome Activator Subunit 3 (PSME3)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-254 of human PSME3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P61289 (UniProt, ExPASy)
UniProt Secondary AC	A8K9A3, O35563, P97373, Q12920, Q13172, Q9BQD9
UniProt Entry Name	PSME3_HUMAN
Gene Symbol	PSME3
GeneID	10197
NCBI Accession	NP_789839.1
KEGG	hsa:10197
String	9606.ENSP00000293362
Molecular Weight	Calculated MW: 30 kDa Observed MW: 32 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Proteasome Activator Subunit 3 (PSME3)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue