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Polypyrimidine Tract-Binding Protein 1 (PTBP1) Antibody

Catalogue No: abx001513
Price: £120.00
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Polypyrimidine Tract-Binding Protein 1 (PTBP1) Antibody

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PTBP1 Antibody is a Rabbit Polyclonal antibody against PTBP1. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been describ.

Target PTBP1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PTBP1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P26599 (UniProt, ExPASy)
UniProt Secondary AC Q9BUQ0
UniProt Entry Name PTBP1_HUMAN
Gene Symbol PTBP1
GeneID 5725
KEGG hsa:5725
String 9606.ENSP00000349428
Molecular Weight Calculated MW: 57 kDa, 59 kDa
Observed MW: 64 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Polypyrimidine Tract-Binding Protein 1 (PTBP1) Antibody

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