PTEN (pY176) Antibody

REQUEST MORE INFO
Catalogue No: abx032258
Price: US$326.25
(Size: 80 µl)

Click on the image to see the image legend

Available Options

* Size:


Add to Shopping Cart Buy It Now GET A QUOTE

Documents

Datasheet SDS
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Target PTEN (pY176)
Clonality Polyclonal
Target Modification Tyr176
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, DB
Host Rabbit
Recommended dilutions DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y176 of human PTEN.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P60484 (UniProt, ExPASy)
UniProt Secondary AC B2R904, F2YHV0, O00633, O02679, Q6ICT7
UniProt Entry Name PTEN_HUMAN
Gene Symbol PTEN
KEGG hsa:5728
String 9606.ENSP00000361021
Enzyme Commission Number EC 3.1.3.16 EC 3.1.3.67 EC 3.1.3.48
Molecular Weight Calculated MW: 47.2 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse and Xenopus PTEN.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on PTEN (pY176)


Write a review

Tags:
(Click to show)