PTEN (pY68) Antibody

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Target	PTEN (pY68)
Clonality	Polyclonal
Target Modification	Tyr68
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y68 of human PTEN.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P60484 (UniProt, ExPASy)
UniProt Secondary AC	B2R904, F2YHV0, O00633, O02679, Q6ICT7
UniProt Entry Name	PTEN_HUMAN
Gene Symbol	PTEN
KEGG	hsa:5728
String	9606.ENSP00000361021
Enzyme Commission Number	EC 3.1.3.16 EC 3.1.3.67 EC 3.1.3.48
Molecular Weight	Calculated MW: 47.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Xenopus PTEN.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PTEN (pY68)

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