Pleiotrophin (PTN) Antibody
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Catalogue No: abx002245
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US$348.00
(Size: 60 µl)
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Datasheet SDS
PTN Antibody is a Rabbit Polyclonal antibody against PTN. Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTNgene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Research Articles on Pleiotrophin (PTN)
| Target | Pleiotrophin (PTN) |
| Research Area | Cytokines, Tumor Immunity, Neuroscience, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human PTN |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P21246 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5U0B0, Q6ICQ5, Q9UCC6 |
| UniProt Entry Name | PTN_HUMAN |
| Gene Symbol | PTN |
| GeneID | 5764 |
| KEGG | hsa:5764 |
| String | 9606.ENSP00000341170 |
| Molecular Weight | Calculated MW: 18 kDa Observed MW: 19 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
