Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody

Catalogue No: abx001339
Price: £160.00
(Size: 20 µl)
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Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody

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PTPN1 Antibody is a Rabbit Polyclonal antibody against PTPN1. The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

Target PTPN1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PTPN1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P18031 (UniProt, ExPASy)
UniProt Secondary AC Q5TGD8, Q9BQV9, Q9NQQ4
UniProt Entry Name PTN1_HUMAN
Gene Symbol PTPN1
GeneID 5770
KEGG hsa:5770
String 9606.ENSP00000360683
Molecular Weight Calculated MW: 49 kDa
Observed MW: 50 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody

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