Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) Antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Target	Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11)
Clonality	Monoclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Human PTPN11 recombinant protein.
Isotype	IgG1 Kappa
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q06124 (UniProt, ExPASy)
UniProt Secondary AC	A8K1D9, Q96HD7
UniProt Entry Name	PTN11_HUMAN
KEGG	hsa:5781
String	9606.ENSP00000340944
Molecular Weight	Calculated MW: 68 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11)

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