PTPN11 (pY542) Antibody

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Catalogue No: abx000318
Price: US$232.00
(Size: 20 µl)

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Datasheet SDS
PTPN11 (pY542) Antibody is a Rabbit Polyclonal antibody against PTPN11 (pY542). The protein encoded by this gene is a member of the protein tyrosine phosphatase (pYP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as pTosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Target PTPN11 (pY542)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic phosphorylated peptide around Y542 of human PTPN11.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q06124 (UniProt, ExPASy)
UniProt Secondary AC A8K1D9, Q96HD7
UniProt Entry Name PTN11_HUMAN
Gene Symbol PTPN11
GeneID 5781
NCBI Accession NP_002825.3
KEGG hsa:5781
String 9606.ENSP00000340944
Molecular Weight Calculated MW: 68 kDa
Observed MW: 72 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on PTPN11 (pY542)


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