Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2) Antibody

PTPN2 Antibody is a Rabbit Polyclonal antibody against PTPN2. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011].

Target	Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human PTPN2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P17706 (UniProt, ExPASy)
UniProt Secondary AC	A8K955, A8MXU3, K7ENG3, Q96AU5, Q96HR2
Gene Symbol	PTPN2
GeneID	5771
NCBI Accession	NP_536348.1
Molecular Weight	Calculated MW: 48 kDa Observed MW: 45 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Tyrosine Phosphatase, Non Receptor Type 2 (PTPN2)

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