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Protein Tyrosine Phosphatase, Non-Receptor Type 6 (PTPN6) Antibody

Catalogue No: abx001240
Price: £120.00
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Protein Tyrosine Phosphatase, Non-Receptor Type 6 (PTPN6) Antibody Protein Tyrosine Phosphatase, Non-Receptor Type 6 (PTPN6) Antibody

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PTPN6 Antibody is a Rabbit Polyclonal antibody against PTPN6. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Target PTPN6
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PTPN6.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P29350 (UniProt, ExPASy)
UniProt Secondary AC A8K306, G3V0F8, Q969V8, Q9UK67
UniProt Entry Name PTN6_HUMAN
Gene Symbol PTPN6
GeneID 5777
KEGG hsa:5777
String 9606.ENSP00000391592
Molecular Weight Calculated MW: 63 kDa, 67 kDa, 70 kDa
Observed MW: 68 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Protein Tyrosine Phosphatase, Non-Receptor Type 6 (PTPN6) Antibody

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