Protein Tyrosine Phosphatase, Non-Receptor Type 6 (PTPN6) Antibody

PTPN6 Antibody is a Rabbit Polyclonal antibody against PTPN6. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Target	Protein Tyrosine Phosphatase, Non-Receptor Type 6 (PTPN6)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human SHP1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P29350 (UniProt, ExPASy)
UniProt Secondary AC	A8K306, G3V0F8, Q969V8, Q9UK67
UniProt Entry Name	PTN6_HUMAN
Gene Symbol	PTPN6
GeneID	5777
NCBI Accession	NP_002822.2
KEGG	hsa:5777
String	9606.ENSP00000391592
Molecular Weight	Calculated MW: 68 kDa Observed MW: 68 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Tyrosine Phosphatase, Non-Receptor Type 6 (PTPN6)

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