PTPN6 (pY536) Antibody is a Rabbit Polyclonal antibody against PTPN6 (pY536). The protein encoded by this gene is a member of the protein tyrosine phosphatase (pYP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein pTosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
| Target |
PTPN6 (pY536) |
| Clonality |
Polyclonal |
| Reactivity |
Human, Mouse, Rat |
| Tested Applications |
IHC, IF/ICC |
| Host |
Rabbit |
| Recommended dilutions |
IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Immunogen |
Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y536 of human PTPN6. |
| Isotype |
IgG |
| Form |
Liquid |
| Purification |
Affinity purified. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC |
P29350 (UniProt,
ExPASy)
|
| UniProt Secondary AC |
A8K306, G3V0F8, Q969V8, Q9UK67 |
| UniProt Entry Name |
PTN6_HUMAN |
| Gene Symbol |
PTPN6 |
| GeneID |
5777
|
| String |
9606.ENSP00000391592
|
| Molecular Weight |
Calculated MW: 63 kDa, 67 kDa, 70 kDa |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration |
> 1 mg/ml |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on PTPN6 (pY536) Antibody
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