Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody

Catalogue No: abx001727
Price: £120.00
(Size: 20 µl)
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PTPRC Antibody is a Rabbit Polyclonal antibody against PTPRC. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Target Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human PTPRC.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P08575 (UniProt, ExPASy)
UniProt Secondary AC A0A0A0MT22, A8K7W6, Q16614, Q9H0Y6, X6R433
UniProt Entry Name PTPRC_HUMAN
Gene Symbol PTPRC
GeneID 5788
KEGG hsa:5788
String 9606.ENSP00000411355
Molecular Weight Calculated MW: 130 kDa, 147 kDa
Observed MW: 185 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)

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