Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody

PTPRC Antibody is a Rabbit Polyclonal antibody against PTPRC. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Target	Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 194-390 of human CD45.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08575 (UniProt, ExPASy)
UniProt Secondary AC	A0A0A0MT22, A8K7W6, Q16614, Q9H0Y6, X6R433
UniProt Entry Name	PTPRC_HUMAN
Gene Symbol	PTPRC
GeneID	5788
NCBI Accession	NP_002829.3
KEGG	hsa:5788
String	9606.ENSP00000411355
Molecular Weight	Calculated MW: 147 kDa Observed MW: 180-240 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)

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