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PYD And CARD Domain Containing (PYCARD) Antibody

Catalogue No: abx001084
Price: £120.00
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PYD And CARD Domain Containing (PYCARD) Antibody PYD And CARD Domain Containing (PYCARD) Antibody

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PYCARD Antibody is a Rabbit Polyclonal antibody against PYCARD. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Target PYCARD
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human PYCARD.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9ULZ3 (UniProt, ExPASy)
UniProt Secondary AC Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8
UniProt Entry Name ASC_HUMAN
Gene Symbol PYCARD
GeneID 29108
String 9606.ENSP00000247470
Molecular Weight Calculated MW: 15 kDa, 19 kDa, 21 kDa
Observed MW: 22 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on PYD And CARD Domain Containing (PYCARD) Antibody

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