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R-Spondin 1 (RSPO1) Antibody
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Catalogue No: abx011430
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US$427.75
(Size: 100 µl)
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Datasheet SDS
R-Spondin 1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF beta pathway. Has a essential roles in ovary determination.
Research Articles on R-Spondin 1 (RSPO1)
| Target | R-Spondin 1 (RSPO1) |
| Research Area | Cytokines, Metabolic Pathways, Bone Metabolism |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of R-spondin1 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q2MKA7 (UniProt, ExPASy) |
| UniProt Secondary AC | A2A420, Q0H8S6, Q14C72, Q5T0F2, Q8N7L5 |
| UniProt Entry Name | RSPO1_HUMAN |
| Gene Symbol | RSPO1 |
| GeneID | 284654 |
| OMIM | 609595 |
| HGNC | 21679 |
| KEGG | hsa:284654 |
| Ensembl | ENSG00000169218 |
| String | 9606.ENSP00000348944 |
| Molecular Weight | 28.9 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |