R-Spondin 1 (RSPO1) Antibody

R-Spondin 1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF beta pathway. Has a essential roles in ovary determination.

Target	R-Spondin 1 (RSPO1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of R-spondin1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q2MKA7 (UniProt, ExPASy)
UniProt Secondary AC	A2A420, Q0H8S6, Q14C72, Q5T0F2, Q8N7L5
UniProt Entry Name	RSPO1_HUMAN
Gene Symbol	RSPO1
GeneID	284654
OMIM	609595
HGNC	21679
KEGG	hsa:284654
Ensembl	ENSG00000169218
String	9606.ENSP00000348944
Molecular Weight	28.9 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on R-Spondin 1 (RSPO1)

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