Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) Antibody

Catalogue No: abx001811
Price: £120.00
(Size: 20 µl)
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RAPGEF3 Antibody is a Rabbit Polyclonal antibody against RAPGEF3. EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6).

Target Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RAPGEF3.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O95398 (UniProt, ExPASy)
UniProt Secondary AC A8K2G5, E7EQC8, O95634, Q8WVN0
UniProt Entry Name RPGF3_HUMAN
Gene Symbol RAPGEF3
GeneID 10411
OMIM 606057
NCBI Accession NP_001092002.1
HGNC 16629
KEGG hsa:10411
Ensembl ENSG00000079337
String 9606.ENSP00000395708
Molecular Weight Calculated MW: 66 kDa, 99 kDa, 103 kDa
Observed MW: 104 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 0.92 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3)

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