Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) Antibody

RAPGEF3 Antibody is a Rabbit Polyclonal antibody against RAPGEF3. EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6).

Target	Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Epac1/Epac1/RAPGEF3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95398 (UniProt, ExPASy)
UniProt Secondary AC	A8K2G5, E7EQC8, O95634, Q8WVN0
UniProt Entry Name	RPGF3_HUMAN
Gene Symbol	RAPGEF3
GeneID	10411
OMIM	606057
NCBI Accession	NP_001092002.1
HGNC	16629
KEGG	hsa:10411
Ensembl	ENSG00000079337
String	9606.ENSP00000395708
Molecular Weight	Calculated MW: 104 kDa Observed MW: 104 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	0.35 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3)

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