Ras GTPase-Activating Protein 1 (RASA1) Antibody
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Catalogue No: abx001377
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US$348.00
(Size: 60 µl)
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Datasheet SDS
RASA1 Antibody is a Rabbit Polyclonal antibody against RASA1. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].
Research Articles on Ras GTPase-Activating Protein 1 (RASA1)
| Target | Ras GTPase-Activating Protein 1 (RASA1) |
| Research Area | Tumor Immunity, Developmental Science, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human RASA1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P20936 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6W3, B4DTL2, Q68CU6, Q9UDI1 |
| UniProt Entry Name | RASA1_HUMAN |
| Gene Symbol | RASA1 |
| GeneID | 5921 |
| NCBI Accession | NP_002881.1 |
| KEGG | hsa:5921 |
| String | 9606.ENSP00000274376 |
| Molecular Weight | Calculated MW: 58 kDa/100 kDa/101 kDa/116 kDa Observed MW: 125 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
