Ras GTPase-Activating Protein 1 (RASA1) Antibody

Catalogue No: abx001377
Price: £120.00
(Size: 20 µl)
Reviews: 0 reviews
(0 reviews)

Click on the image to see the image legend

Available Options

* Size:




RASA1 Antibody is a Rabbit Polyclonal antibody against RASA1. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].

Target RASA1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human RASA1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P20936 (UniProt, ExPASy)
UniProt Secondary AC B2R6W3, B4DTL2, Q68CU6, Q9UDI1
UniProt Entry Name RASA1_HUMAN
Gene Symbol RASA1
GeneID 5921
KEGG hsa:5921
String 9606.ENSP00000274376
Molecular Weight Calculated MW: 58 kDa, 100 kDa, 101 kDa, 116 kDa
Observed MW: 125 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on RASA1

Write a review

Your Name
Your Email Address
PMID
DOI
Your Review

Note: HTML is not translated!

Rating Bad Good

Tags:
(Click to show)