Ras-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Antibody
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Catalogue No: abx005283
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US$217.50
(Size: 20 µl)
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Datasheet SDS
RASGRF1 Antibody is a Rabbit Polyclonal antibody against RASGRF1. The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Research Articles on Ras-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1)
| Target | Ras-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) |
| Research Area | Signaling Pathways, G Protein-Coupled Receptors Signaling |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to RASGRF1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13972 (UniProt, ExPASy) |
| UniProt Secondary AC | F8VPA5, H0YKF2, J3KQP9, Q16027 |
| UniProt Entry Name | RGRF1_HUMAN |
| Gene Symbol | RASGRF1 |
| GeneID | 5923 |
| OMIM | 606600 |
| NCBI Accession | NP_001139120.1 |
| HGNC | 9875 |
| KEGG | hsa:5923 |
| Ensembl | ENSG00000058335 |
| String | 9606.ENSP00000405963 |
| Molecular Weight | Calculated MW: 145 kDa Observed MW: 145 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |