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Retinoblastoma Protein 1 Phospho-Ser811 (RB1 pS811) Antibody
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Catalogue No: abx000161
Price:
US$232.00
(Size: 20 µl)
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RB1 (pS811) Antibody is a Rabbit Polyclonal antibody against RB1 (pS811). The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB1), bladder cancer, and osteogenic sarcoma.
Research Articles on Retinoblastoma Protein 1 Phospho-Ser811 (RB1 pS811)
| Target | Retinoblastoma Protein 1 Phospho-Ser811 (RB1 pS811) |
| Clonality | Polyclonal |
| Target Modification | Ser811 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around S811 of human RB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P06400 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5E3, P78499, Q5VW46, Q8IZL4 |
| UniProt Entry Name | RB_HUMAN |
| Gene Symbol | RB1 |
| GeneID | 5925 |
| NCBI Accession | NP_000312.2 |
| KEGG | hsa:5925 |
| String | 9606.ENSP00000267163 |
| Molecular Weight | Calculated MW: 106 kDa Observed MW: 106 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |