Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780) Antibody

Catalogue No: abx000491
Price: £230.00
(Size: 50 µl)

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Datasheet SDS
RB1 (pS780) Antibody is a Rabbit Polyclonal antibody against RB1 (pS780). The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Target Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780)
Clonality Polyclonal
Target Modification Ser780
Modification Phosphorylation
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S780 of human RB1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P06400 (UniProt, ExPASy)
UniProt Secondary AC A8K5E3, P78499, Q5VW46, Q8IZL4
UniProt Entry Name RB_HUMAN
Gene Symbol RB1
GeneID 5925
KEGG hsa:5925
String 9606.ENSP00000267163
Molecular Weight Calculated MW: 106 kDa
Observed MW: 110 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780)

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