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Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780) Antibody
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Catalogue No: abx000491
Price:
£230.00
(Size: 50 µl)
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RB1 (pS780) Antibody is a Rabbit Polyclonal antibody against RB1 (pS780). The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Research Articles on Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780)
| Target | Retinoblastoma Protein 1 Phospho-Ser780 (RB1 pS780) |
| Clonality | Polyclonal |
| Target Modification | Ser780 |
| Modification | Phosphorylation |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S780 of human RB1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P06400 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5E3, P78499, Q5VW46, Q8IZL4 |
| UniProt Entry Name | RB_HUMAN |
| Gene Symbol | RB1 |
| GeneID | 5925 |
| KEGG | hsa:5925 |
| String | 9606.ENSP00000267163 |
| Molecular Weight | Calculated MW: 106 kDa Observed MW: 110 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
