Renin (REN) Antibody
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Catalogue No: abx001335
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US$217.50
(Size: 20 µl)
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Datasheet SDS
REN Antibody is a Rabbit Polyclonal antibody against REN. Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Research Articles on Renin (REN)
| Target | Renin (REN) |
| Research Area | Endocrinology, Cardiovascular Biology, Kidney Biomarker, Hormone Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/100 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to REN. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P00797 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6FI38, Q6T5C2 |
| UniProt Entry Name | RENI_HUMAN |
| Gene Symbol | REN |
| GeneID | 5972 |
| NCBI Accession | NP_000528.1 |
| KEGG | hsa:5972 |
| String | 9606.ENSP00000272190 |
| Molecular Weight | Calculated MW: 45 kDa Observed MW: 46 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |