RE1 Silencing Transcription Factor (REST) Antibody
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Catalogue No: abx029206
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Research Articles on RE1 Silencing Transcription Factor (REST)
| Target | RE1 Silencing Transcription Factor (REST) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 542-570 amino acids from the Central region of human REST. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13127 (UniProt, ExPASy) |
| UniProt Secondary AC | A2RUE0, B9EGJ0, Q12956, Q12957, Q13134, Q59ER1, Q8IWI3 |
| UniProt Entry Name | REST_HUMAN |
| KEGG | hsa:5978 |
| String | 9606.ENSP00000311816 |
| Molecular Weight | Calculated MW: 122 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |