Retinol (RET) Antibody

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Catalogue No: abx016052
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation.It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement.Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin.Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung disease.The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity.Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.

Target Retinol (RET)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA
Host Mouse
Recommended dilutions ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of RET (aa896-1063) expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P07949 (UniProt, ExPASy)
UniProt Secondary AC A8K6Z2, Q15250, Q9BTB0, Q9H4A2
Gene Symbol RET
GeneID 5979
OMIM 114500
HGNC 9967
Ensembl ENSG00000165731
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Retinol (RET)


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