DNA-Binding Protein RFX5 (RFX5) Antibody

RFX5 Antibody is a Rabbit Polyclonal antibody against RFX5. A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

Target	DNA-Binding Protein RFX5 (RFX5)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	IF/ICC
Host	Rabbit
Recommended dilutions	IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 367-616 of human RFX5.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48382 (UniProt, ExPASy)
UniProt Secondary AC	B7Z848, D3DV19, E9PFU4, Q5VWC3
UniProt Entry Name	RFX5_HUMAN
Gene Symbol	RFX5
GeneID	5993
OMIM	209920
NCBI Accession	NP_000440.1
HGNC	9986
KEGG	hsa:5993
Ensembl	ENSG00000143390
String	9606.ENSP00000290524
Molecular Weight	Calculated MW: 65 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA-Binding Protein RFX5 (RFX5)

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