Rapamycin-Insensitive Companion of mTOR (RICTOR) Antibody

Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size.The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals.mTOR is a large protein kinase with two different complexes.One complex contains mTOR, G beta L and raptor, which is a target of rapamycin.The other complex, insensitive to rapamycin, includes mTOR, G beta L, Sin1 and rictor.The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro.This phosphorylation is essential for full Akt/PKB activation.Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes.This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR.

Target	Rapamycin-Insensitive Companion of mTOR (RICTOR)
Clonality	Monoclonal
Reactivity	Human, Monkey, Mouse
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human RICTOR expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q6R327 (UniProt, ExPASy)
UniProt Secondary AC	B2RNX0, B7ZMF7, Q68DT5, Q86UB7, Q8N3A0, Q8NCM6
UniProt Entry Name	RICTR_HUMAN
Gene Symbol	RICTOR
GeneID	253260
OMIM	609022
HGNC	28611
KEGG	hsa:253260
Ensembl	ENSG00000164327
String	9606.ENSP00000296782
Molecular Weight	192 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Rapamycin-Insensitive Companion of mTOR (RICTOR)

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