Rho-Associated Protein Kinase 1 (ROCK1) Antibody
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Catalogue No: abx012064
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Research Articles on Rho-Associated Protein Kinase 1 (ROCK1)
| Target | Rho-Associated Protein Kinase 1 (ROCK1) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ROCK1 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13464 (UniProt, ExPASy) |
| UniProt Secondary AC | B0YJ91, Q2KHM4, Q59GZ4 |
| UniProt Entry Name | ROCK1_HUMAN |
| Gene Symbol | ROCK1 |
| GeneID | 6093 |
| OMIM | 601702 |
| HGNC | 10251 |
| KEGG | hsa:6093 |
| Ensembl | ENSG00000067900 |
| String | 9606.ENSP00000382697 |
| Molecular Weight | 158 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |