Ribosomal Protein S6 Kinase Beta 1 (RPS6KB1) Antibody

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases.This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein.The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation.Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines.Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.

Target	Ribosomal Protein S6 Kinase Beta 1 (RPS6KB1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human RPS6KB1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P23443 (UniProt, ExPASy)
UniProt Secondary AC	B2R779, B4DLT4, B4DTG1, E7ESB8, F6UYM1, Q7Z721
UniProt Entry Name	KS6B1_HUMAN
Gene Symbol	RPS6KB1
GeneID	6198
OMIM	608938
HGNC	10436
KEGG	hsa:6198
Ensembl	ENSG00000108443
String	9606.ENSP00000225577
Molecular Weight	59 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ribosomal Protein S6 Kinase Beta 1 (RPS6KB1)

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