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Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Antibody
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Catalogue No: abx001066
Price:
US$348.00
(Size: 60 µl)
Orders to United States ship from United States
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RRM1 Antibody is a Rabbit Polyclonal antibody against RRM1. This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.
Research Articles on Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1)
| Target | Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human RRM1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P23921 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9UNN2 |
| UniProt Entry Name | RIR1_HUMAN |
| Gene Symbol | RRM1 |
| GeneID | 6240 |
| NCBI Accession | NP_001024.1 |
| KEGG | hsa:6240 |
| String | 9606.ENSP00000300738 |
| Molecular Weight | Calculated MW: 90 kDa Observed MW: 90 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
