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Ribonucleoside-Diphosphate Reductase Subunit M2 (RRM2) Antibody
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Catalogue No: abx004031
Price:
US$217.50
(Size: 20 µl)
Orders to United States ship from United States
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RRM2 Antibody is a Rabbit Polyclonal antibody against RRM2. Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5'-diphosphates into 2'-deoxyribonucleotides, a rate-limiting step in the production of 2'-deoxyribonucleoside 5'-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair [PMID:20825972, 19250552]. RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit.
Research Articles on Ribonucleoside-Diphosphate Reductase Subunit M2 (RRM2)
| Target | Ribonucleoside-Diphosphate Reductase Subunit M2 (RRM2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to RRM2. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P31350 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R9B5, J3KP43, Q5WRU7 |
| UniProt Entry Name | RIR2_HUMAN |
| Gene Symbol | RRM2 |
| GeneID | 6241 |
| NCBI Accession | NP_001025.1 |
| KEGG | hsa:6241 |
| String | 9606.ENSP00000353770 |
| Molecular Weight | Calculated MW: 45 kDa Observed MW: 45 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 0.60 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |