Runt-Related Transcription Factor 2 (RUNX2) Antibody

RUNX2 Antibody is a Rabbit Polyclonal antibody against RUNX2. This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Target	Runt-Related Transcription Factor 2 (RUNX2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 242-521 of human RUNX2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13950 (UniProt, ExPASy)
UniProt Secondary AC	O14614, O14615, O95181
UniProt Entry Name	RUNX2_HUMAN
Gene Symbol	RUNX2
GeneID	860
NCBI Accession	NP_001019801.3
KEGG	hsa:860
String	9606.ENSP00000360493
Molecular Weight	Calculated MW: 57 kDa Observed MW: 60 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	0.917 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Runt-Related Transcription Factor 2 (RUNX2)

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