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Runt-Related Transcription Factor 2 (RUNX2) Antibody

Catalogue No: abx002106
Price: £120.00
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Runt-Related Transcription Factor 2 (RUNX2) Antibody

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RUNX2 Antibody is a Rabbit Polyclonal antibody against RUNX2. This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Target RUNX2
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human RUNX2.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13950 (UniProt, ExPASy)
UniProt Secondary AC O14614, O14615, O95181
UniProt Entry Name RUNX2_HUMAN
Gene Symbol RUNX2
GeneID 860
KEGG hsa:860
String 9606.ENSP00000360493
Molecular Weight Calculated MW: 54 kDa, 55 kDa, 56 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Runt-Related Transcription Factor 2 (RUNX2) Antibody

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