RuvB-Like 1/Pontin 52 (RUVBL1) Antibody

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation. This antibody is supplied as crude ascites.

Target	RuvB-Like 1/Pontin 52 (RUVBL1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/8000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified His-tagged Human RUVBL1 protein (Fragment)
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y265 (UniProt, ExPASy)
UniProt Secondary AC	B2R5S0, P82276, Q1KMR0, Q53HK5, Q53HL7, Q53Y27, Q9BSX9
UniProt Entry Name	RUVB1_HUMAN
String	9606.ENSP00000318297
Enzyme Commission Number	EC 3.6.1 EC 3.6.4.12
Molecular Weight	Calculated MW: 50.2 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Please enquire.
Note	This product is for research use only.

Research Articles on RuvB-Like 1/Pontin 52 (RUVBL1)

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