Ryanodine Receptor 1, Skeletal (RYR1) Antibody
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Catalogue No: abx110194
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US$188.50
(Size: 20 µg)
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Datasheet SDS
RYR1 is a calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of t-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. RYR1 can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. It is required for normal embryonic development of muscle fibers, skeletal muscle, normal heart morphogenesis, skin development and ossification.
Research Articles on Ryanodine Receptor 1, Skeletal (RYR1)
| Target | Ryanodine Receptor 1, Skeletal (RYR1) |
| Research Area | Neuroscience |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant human Ryanodine receptor 1 protein (1-534 AA). |
| Isotype | IgG |
| Form | Liquid |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P21817 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16314, Q16368, Q9NPK1, Q9P1U4 |
| UniProt Entry Name | RYR1_HUMAN |
| Gene Symbol | RYR1 |
| GeneID | 6261 |
| OMIM | 117000 |
| NCBI Accession | NP_000531.2 NM_000540.2 |
| KEGG | hsa:6261 |
| String | 9606.ENSP00000352608 |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |