SARS-CoV-2 Envelope Protein Antibody

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Envelope Protein Antibody is a Rabbit Polyclonal antibody for the detection of SARS-CoV-2 Envelope Protein.

Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

Target	SARS-CoV-2
Clonality	Polyclonal
Reactivity	Virus
Tested Applications	ELISA
Host	Rabbit
Recommended dilutions	ELISA: 1/4000 - 1/8000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant SARS-CoV-2 E protein (Met1-Val75)
Isotype	IgG
Form	Liquid
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Buffer	PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Concentration	1.08 mg/ml
Availability	Shipped within 5-15 working days.
Note	This product is for research use only.
Directions for use	Centrifuge before opening to ensure complete recovery of vial contents.

Research Articles on SARS-CoV-2

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