SARS-CoV-2 Spike Neutralizing Antibody

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike Neutralizing Antibody is a Human monoclonal IgG1 antibody.

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the S1 and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

Target	SARS-CoV-2
Clonality	Monoclonal
Reactivity	Virus
Tested Applications	ELISA
Host	Human
Recommended dilutions	ELISA: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant SARS-CoV-2 S-trimer Protein
Isotype	IgG1
Form	Liquid
Purification	Purified by Protein A affinity chromatography.
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Buffer	PBS, pH 7.4.
Concentration	1 mg/ml
Availability	Shipped within 5-15 working days.
Note	This product is for research use only.
Directions for use	Centrifuge before opening to ensure complete recovery of vial contents.

Research Articles on SARS-CoV-2

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