SARS-CoV-2 Trimeric Spike 1 Protein Antibody

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Trimeric Spike 1 Protein Antibody is a Mouse Monoclonal Antibody against SARS-CoV-2/COVID-19 Trimeric S1 Protein.

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the S1 and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

This antibody is designed to work with saliva patient samples that do not require lysis. It is recommended to use abx024240 (this antibody) as the capture antibody and abx024241 as the detection antibody. In an ELISA with TMB substrate, this pair can detect SARS-CoV-2 trimeric spike protein with a sensitivity of approximately 300 pg/ml.

Target	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Trimeric Spike 1 Protein
Clonality	Monoclonal
Clone	H662
Reactivity	Virus
Tested Applications	ELISA, WB, LF
Host	Mouse
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant SARS-CoV-2 S1 Protein
Epitope Region	Recognizes a linear epitope that is not conformation-dependent.
Isotype	IgG1
Form	Liquid
Purity	> 90%
Purification	Purified by Protein A affinity chromatography.
Storage	Store at 2°C to 8°C.
Buffer	PBS, pH 7.4. Does not contain preservatives.
Specificity	Binds to recombinant SARS-CoV-2 trimeric spike protein. Recognizes the membrane bound form from the cell line expressing full-length SARS-CoV-2 protein. This antibody is specific to SARS-CoV-2 Spike trimeric protein and does not cross-react with recombinant SARS-CoV, HCoV-229E, HCoV-HKU1, HCoV-NL63 and HCoV-OC43.
Concentration	1.63 mg/ml
Availability	Shipped within 10-20 working days.
Note	This product is for research use only.
Directions for use	Centrifuge before opening to ensure complete recovery of vial contents.

Research Articles on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Trimeric Spike 1 Protein

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