Succinate Dehydrogenase Complex Subunit B (SDHB) Antibody
REQUEST MORE INFO
Catalogue No: abx031320
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
(
Click on the image to see the image legend
Add to Cart
Buy It Now
GET A QUOTE
Documents
Datasheet SDS
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Research Articles on Succinate Dehydrogenase Complex Subunit B (SDHB)
| Target | Succinate Dehydrogenase Complex Subunit B (SDHB) |
| Research Area | Tumor Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P21912 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R545, Q0QEY7, Q9NQ12 |
| UniProt Entry Name | SDHB_HUMAN |
| Gene Symbol | SDHB |
| KEGG | hsa:6390 |
| String | 9606.ENSP00000364649 |
| Molecular Weight | Calculated MW: 31.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Cow and Pig SDHB. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |