Septin 2 (SEPTIN2) Antibody

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Target	Septin 2 (SEPTIN2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human SEPT2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15019 (UniProt, ExPASy)
UniProt Secondary AC	B4DGE8, Q14132, Q53QU3, Q8IUK9, Q96CB0
UniProt Entry Name	SEPT2_HUMAN
KEGG	hsa:4735
String	9606.ENSP00000479861
Molecular Weight	Calculated MW: 41.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow SEPTIN2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Septin 2 (SEPTIN2)

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