Pigment Epithelium-Derived Factor / PEDF (SERPINF1) Antibody

Pigment Epithelium-Derived Factor / PEDF (SERPINF1) Antibody is a Rabbit Polyclonal antibody against SERPINF1. Pigment epithelium-derived growth factor (PEDF), also known as EPC-1 (early population doubling level cDNA-1), is a glycoprotein found naturally in the normal eye. PEDF has reported neuroprotective and differentiation properties and is secreted in abundance by retinal pigment epithelium cells. It belongs to the serine protease inhibitor (Serpin) superfamily and has been reported to inhibit angiogenesis and proliferation of several cell types. The pooling of PEDF within the interphotoreceptor matrix places this molecule in a prime physical location to affect the underlying neural retina. Additionally, PEDF induces neuronal differentiation and promotes survival of neurons of the central nervous system from degeneration caused by serum withdrawal or glutamate cytotoxicity.

Target	Pigment Epithelium-Derived Factor / PEDF (SERPINF1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 141-240 of human PEDF/SERPINF1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P36955 (UniProt, ExPASy)
UniProt Secondary AC	F1T092, Q13236, Q2TU83, Q96CT1, Q96R01, Q9BWA4
UniProt Entry Name	PEDF_HUMAN
Gene Symbol	SERPINF1
GeneID	5176
OMIM	172860
NCBI Accession	NP_002606.3
HGNC	8824
KEGG	hsa:5176
Ensembl	ENSG00000132386
String	9606.ENSP00000254722
Molecular Weight	Calculated MW: 46 kDa Observed MW: 46 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Pigment Epithelium-Derived Factor / PEDF (SERPINF1)

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