SET Domain Containing Protein 2 (SETD2) Antibody

SETD2 Antibody is a Rabbit Polyclonal antibody against SETD2. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

Target	SET Domain Containing Protein 2 (SETD2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/400-600 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 2475-2564 of human SETD2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9BYW2 (UniProt, ExPASy)
UniProt Entry Name	SETD2_HUMAN
Gene Symbol	SETD2
GeneID	29072
NCBI Accession	NP_054878.5
String	9606.ENSP00000386759
Molecular Weight	Calculated MW: 288 kDa Observed MW: 288 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	1.23 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on SET Domain Containing Protein 2 (SETD2)

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