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Splicing Factor 3b Subunit 1 (SF3B1) Antibody
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Catalogue No: abx027583
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US$326.25
(Size: 80 µl)
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Datasheet SDS
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Research Articles on Splicing Factor 3b Subunit 1 (SF3B1)
| Target | Splicing Factor 3b Subunit 1 (SF3B1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 374-402 amino acids from the N-terminal region of human SF3B1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O75533 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PCH3 |
| UniProt Entry Name | SF3B1_HUMAN |
| Gene Symbol | SF3B1 |
| KEGG | hsa:23451 |
| String | 9606.ENSP00000335321 |
| Molecular Weight | Calculated MW: 146 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Xenopus SF3B1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |