14-3-3 Protein Sigma (SFN) Antibody

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Catalogue No: abx000967
Price: US$217.50
(Size: 20 µl)

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14-3-3 Protein Sigma (SFN) Antibody 14-3-3 Protein Sigma (SFN) Antibody 14-3-3 Protein Sigma (SFN) Antibody 14-3-3 Protein Sigma (SFN) Antibody 14-3-3 Protein Sigma (SFN) Antibody

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Datasheet SDS
SFN Antibody is a Rabbit Polyclonal antibody against SFN. 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.

Target 14-3-3 Protein Sigma (SFN)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic peptide corresponding to SFN. The exact sequence is proprietary.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P31947 (UniProt, ExPASy)
UniProt Secondary AC Q6FH30, Q6FH51, Q96DH0
UniProt Entry Name 1433S_HUMAN
Gene Symbol SFN
GeneID 2810
NCBI Accession NP_006133.1
KEGG hsa:2810
String 9606.ENSP00000340989
Molecular Weight Calculated MW: 28 kDa
Observed MW: 28 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on 14-3-3 Protein Sigma (SFN)


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