Pulmonary Surfactant Associated Protein C (SFTPC) Antibody

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Target	Pulmonary Surfactant Associated Protein C (SFTPC)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/200, IF/ICC: 1/25, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SFTPC.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P11686 (UniProt, ExPASy)
UniProt Secondary AC	A6XNE4, B2RE00, E9PGX3, P11687, Q12793, Q7Z5D0
UniProt Entry Name	PSPC_HUMAN
Gene Symbol	SFTPC
GeneID	6440
KEGG	hsa:6440
String	9606.ENSP00000316152
Molecular Weight	Calculated MW: 21.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow SFTPC.
Concentration	0.5 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Pulmonary Surfactant Associated Protein C (SFTPC)

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