Pulmonary Surfactant-Associated Protein C (SFTPC) Antibody
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Catalogue No: abx001517
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US$348.00
(Size: 60 µl)
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Datasheet SDS
SFTPC Antibody is a Rabbit Polyclonal antibody against SFTPC. This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
Research Articles on Pulmonary Surfactant-Associated Protein C (SFTPC)
| Target | Pulmonary Surfactant-Associated Protein C (SFTPC) |
| Research Area | Tumor Immunity, Infection Immunity, Pulmonology, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human SFTPC |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P11686 (UniProt, ExPASy) |
| UniProt Secondary AC | A6XNE4, B2RE00, E9PGX3, P11687, Q12793, Q7Z5D0 |
| UniProt Entry Name | PSPC_HUMAN |
| Gene Symbol | SFTPC |
| GeneID | 6440 |
| OMIM | 178620 |
| NCBI Accession | NP_003009.2 |
| HGNC | 10802 |
| KEGG | hsa:6440 |
| Ensembl | ENSG00000168484 |
| String | 9606.ENSP00000316152 |
| Molecular Weight | Calculated MW: 20 kDa/21 kDa Observed MW: 21 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
