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SH2 Domain Containing 1A (SH2D1A) Antibody

Catalogue No: abx001057
Price: £120.00
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SH2D1A Antibody is a Rabbit Polyclonal antibody against SH2D1A. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Target SH2D1A
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human SH2D1A.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O60880 (UniProt, ExPASy)
UniProt Secondary AC A8MSW0, O95383, O95384, O95385, O95386, Q6FGS6, Q9UNR0
UniProt Entry Name SH21A_HUMAN
Gene Symbol SH2D1A
GeneID 4068
KEGG hsa:406
String 9606.ENSP00000360181
Molecular Weight Calculated MW: 6 kDa, 8 kDa, 13 kDa, 14 kDa
Observed MW: 17 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on SH2 Domain Containing 1A (SH2D1A) Antibody

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