SH2 Domain Containing 1A (SH2D1A) Antibody

SH2D1A Antibody is a Rabbit Polyclonal antibody against SH2D1A. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	SH2 Domain Containing 1A (SH2D1A)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human SH2D1A.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O60880 (UniProt, ExPASy)
UniProt Secondary AC	A8MSW0, O95383, O95384, O95385, O95386, Q6FGS6, Q9UNR0
UniProt Entry Name	SH21A_HUMAN
Gene Symbol	SH2D1A
GeneID	4068
NCBI Accession	NP_002342.1
KEGG	hsa:4068
String	9606.ENSP00000360181
Molecular Weight	Calculated MW: 14 kDa Observed MW: 17 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on SH2 Domain Containing 1A (SH2D1A)

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