SH2 Domain Containing 1A (SH2D1A) Antibody
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Catalogue No: abx001057
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US$217.50
(Size: 20 µl)
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Datasheet SDS
SH2D1A Antibody is a Rabbit Polyclonal antibody against SH2D1A. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Articles on SH2 Domain Containing 1A (SH2D1A)
| Target | SH2 Domain Containing 1A (SH2D1A) |
| Research Area | Signal Transduction |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to SH2D1A. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O60880 (UniProt, ExPASy) |
| UniProt Secondary AC | A8MSW0, O95383, O95384, O95385, O95386, Q6FGS6, Q9UNR0 |
| UniProt Entry Name | SH21A_HUMAN |
| Gene Symbol | SH2D1A |
| GeneID | 4068 |
| NCBI Accession | NP_002342.1 |
| KEGG | hsa:4068 |
| String | 9606.ENSP00000360181 |
| Molecular Weight | Calculated MW: 14 kDa Observed MW: 17 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |